Informatics Publishing Limited

N. Narayanan ¹, R. Gowri ¹, A. Maheswaran ¹, G. Harshapriya ¹, N. Deattu ², N. R. Ravi Nargis ³

Affiliations
1 Jaya College of Pharmacy, Thiruninravur - 602024, Chennai, Tamil Nadu, IN
2 Government College of Pharmacy, Madras Medical College, Chennai -600 003, IN
3 JSS Medical College for Ayurveda, Alanahally, Mysore - 570 028, IN

Abstract

Purpose: WHO estimates that more than 346 million people worldwide have diabetes. Majority of the population today is not just trying to be economically successful but also aim to stay fit and free from dreaded chronic diseases. This investigation aims to evaluate the health conditions of people from remote areas who have less possibility of utilizing the urban health facilities of India. Methodology: A cross sectional study was conducted to clinically assess diabetes in rural population of Thiruvaliur district by using a predesigned and pretested protocol to find out the prevalence and the risk of diabetes mellitus in general population. The study mainly focuses on rural population so as to suggest possible treatment and remedial aspects. Various studies in the test used are based on simple anthropometric, demographic and behavioral factors to detect undiagnosed diabetes. The responses for the questions were collected, evaluated and statistically analyzed. Findings: Out of 250 subjects, only 5% showed symptoms of diabetes (first time diagnosis) and among them half were in the early stage of the disorder. Conclusion: This study reveals that diabetes awareness prevailed among selected individuals about the hygienic system and life style. It was found that people acquired maximum knowledge with better understanding of the disease, better impact on the progression of the disease and complications by patient counseling through verbal and pictograms.

Keywords

Diabetes, Health Conditions, Rural Population, Anthropometric, Demographic.

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I. Nishanth ¹, K. Elango ¹, N. Deattu ¹, P. Stephen ¹

Affiliations
1 Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai-600003, Tamil Nadu, IN

Abstract

The aim of the study was to design bilayer tablets containing Telmisartan for immediate release and Metformin hydrochloride for sustained release. Telmisartan has the strongest binding affinity to AT1 receptor among various ARBs and also has positive effects on insulin resistance syndrome because of the partial agonistic activity towards peroxisome proliferator-activated receptor-gamma (PPARγ). Metformin is an antihyperglycemic not a hypoglycemic. Combinations of both drugs effect the treatment of hypertension in Type-II diabetes mellitus patients and improve the patient compliance. Telmisartan belongs to class II drug in BCS classification. Enhancement of solubility of Telmisartan was observed with physical mixture of drug with beta (β)-Cyclodextrin. Immediate release layers were prepared by wet granulation method using various concentration of sodium starch glycolate as superdisintegrant. SR layers were prepared by wet granulation method using swellable polymer HPMC K4 M and HPMC K100 M in different ratios. Both Immediate (L1, L2 and L3) and Sustained release (F1, F2, F3, F4 and F5) tablets were formulated and evaluated. All the values were found to be satisfactory and were within limits. From the results obtained I3 and S5 were selected and finally compressed into bilayer tablets. In vitro release studies were carried out using USP type II paddle apparatus in 0.1M HCl for first 2 hours and pH 6.8 phosphate buffer solution for next 8 hours as dissolution medium. Stability studies were carried out at 40 ± 2°c and 75±5% RH for a period of three months.

Keywords

Telmisartan, Metformin Hydrochloride, Bilayer Tablet, Wet Granulation.

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